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人表皮角质形成细胞,包皮
Human Epidermal Keratinocytes, derived from foreskin
产品编号: C-12001
规  格:
单  价: 7379元
生 产 商: PromoCell
到货时间: 4weeks
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角质化细胞

正常的人类皮肤角质形成细胞(NHEK) 分离自青少年包皮的表皮,以及成年人各个部位的皮肤,例如面部、乳房、腹部和大腿*。这些细胞是表皮中的主要细胞类型,占据了细胞总数的90%。

表皮角质化细胞来自皮肤基底层,能穿过表皮各个层次上移。在这个移动过程中,这些细胞逐渐分化,并产生形态学改变,直到到达皮肤的角质层,在角质层,这些细胞形成一层无核的、扁平的和高度角质化的鳞状细胞。这层细胞形成一层有效的屏障,防止外来物质进入到机体,同时尽可能降低水分流失。

角质化细胞也能够产生一系列细胞因子、生长因子、白细胞介素和补体因子。因此,角质化细胞对伤口愈合、炎症和免疫应答都具有重要作用。

Keratinocytes

Primary Normal Human Epidermal Keratinocytes (NHEK) are available from single or from pooled donors isolated from the epidermis of juvenile foreskin or adult skin from different locations like the face, the breasts, the abdomen, and the thighs. They are the major cell type in the epidermis, making up about 90% of the cells.   
(Normal Human Dermal Fibroblasts (NHDF) and Normal Human Epidermal Melanocytes (NHEM) cultured in M2 medium from the same donor are available on request.)

Epidermal keratinocytes originate in the  stratum basale and move up through the layers of the epidermis. During this movement, they undergo gradual differentiation and morphology changes until they reach the  stratum corneum, where they form a layer of nucleus-free, flat, and highly keratinized squamous cells. This layer forms an effective barrier to the entry of infectious agents into the body and minimizes moisture loss.

Keratinocytes are also able to produce a variety of cytokines, growth factors, interleukins and complement factors. Therefore keratinocytes are important for wound healing, inflammation, and immune response.

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